Light?Driven Enantioselective Synthesis of Pyrroline Derivatives by a Radical/Polar Cascade Reaction

Herein, a light-driven, atom-economical process that provides access to enantiomerically enriched substituted chiral 1-pyrroline derivatives is introduced. The strategy involves the distal functionalization of acyl heterocycles through hydrogen-atom transfer (HAT) and use tailor-made ketimines as reliable electrophilic partners. This transformation translated into an controlled radical/polar cascade reaction in which water produced sole by-product stereoselectivity dictated by coordination chiral-at-rhodium catalyst.